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KMID : 0365220150520010011
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Korean Journal of Public Health
2015 Volume.52 No. 1 p.11 ~ p.19
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Concepts and Strategies of the Human Intestinal Microbiome Research
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You Hyun-Ju
Lee Sung-Hee
Ko Gwang-Pyo
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Abstract
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The human gut is the natural habitat for a diverse and dynamic microbial ecosystem, and is the primary site of interaction between the host immune system and microorganisms, both symbiotic and pathogenic. Over the years, global leading groups including HMP, Meta-HIT, and IHMC, have investigated the relationship between human and the gut microbiome. The results let us know that the gut microbiota contribute to host physiology including energy harvest from food and development of immune system, and changes in the gut microbiome are associated with many disease phenotypes. Applying suitable model organisms to verify the causal effect of microbial alteration on host’s biological function has played a vital role in aspect of providing various experimental settings that are not performable in human studies. Next generation sequencing platforms and bioinformatics tools have co-evolved, and resulted in an explosion and development of the microbiome studies. In this report, brief overview of the gut microbiome research along with cutting-edge technologies is reviewed in order to help the readers interested in this emerging field.
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KEYWORD
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Intestinal microbiome, Metagenomics, Next generation sequencing, Probiotics
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